NAD+ is a coenzyme present in all the cells, and is necessary for the electron transfer processduring the reactions of our metabolism to produce our ATP energy!
Cells and evidently humans just can’t live or survive without NAD+.
Scientists have discovered that most deaths of our cells and most diseases happen when our cellular stock of NAD+ is totally depleted.
NAD+ is also crucial for cells communication and signalling, and its absence completely disorganises our organism!
The company Biotrends (based in Hong-Kong) is the only one in the world to allow individuals to access this priceless product, at the cutting edge of scientific discoveries in the domain of fighting ageing.
More and more companies and scientists are investing their time and money in research against aging. For 10 years the tracks have been widening and the results are accumulating.
Yes, we can already act, and indeed for a few years already, by adapting our way of life and nourishment, but above all by optimizing the functioning of our cells because they are indeed the basis of our physical being.
You know of course that I have taken the bull by the horns since 2012, after a diagnosis of prostate tumor. And that I had the immense chance to try epitalon, which straight from the first days gave me fantastic results, because my very troublesome symptoms disappeared almost as if by a miracle!
Combating aging is therefore possible. Rejuvenating is a real reality, and I invite you to try to have proof for yourself.
Then in 2015 Biotrends added another layer, making available to individuals its second anti-aging product after epitalon!
This molecule that brings pure energy to all our cells, and that does even more than that according to scientists!
The french magazine Health Science and Conscience also speaks of it in its latest June issue.
It mentions that scientists have identified a cellular mechanism that reverses the aging of DNA!
It is thus possible to activate the DNA repair process, but also to cancel out the existing effects.
It was in 2013 that Professor Sinclair and his team discovered that the cells of young mice contain more oxidized Nicotinamide Adenine Dinucleotide than those of older mice. And by injecting them with this molecule, they showed all the signs of youth, proving that they had rejuvenated.
As you had guessed I am sure, this is NAD+, a form of pure energy that allows cells to start working instantly to repair and multiply. It is a shortcut to reinvigorate our aged cells which are tired and have problems to produce their operating energy because of the rarefaction of their mitochondria.
Since then, scientific studies have continued, and Professor Sinclair has understood in detail the other mechanism of rejuvenation of NAD+, which is the protection of DNA against the damage caused by aging and radiation.
Our cells gradually lose their ability to repair the errors of mutation and degradation of our DNA during their divisions.
But when there is a lot of NAD+ present in the cell, it prevents this damage on the DNA!
This mechanism of rejuvenation is already exploited by many companies that market a precursor of NAD+, ie a molecule that can potentially transform into NAD+.
But this precursor, although cheaper, has only a very weak action against aging compared to true NAD+.
The NAD+ manufactured by Biotrends is the real and only product that can really give you an awesome rejuvenation shot. Of course it’s because it is more complicated and expensive to manufacture that large groups give up on it.
Their cheap precursor called NMN will not help you, you will see it for yourself if you try it.
On the other hand, pure NAD+ that will be directly usable by your cells will give you a surprising effect, as was the case for me.
I actually felt a growing strength in me, only a few tens of minutes after taking the equivalent of 300mg of NAD+.
At the time it was small pills of only 30 mg each, while now they are 100 mg capsules or 60 grams powder for even more spectacular effects, and at lower cost.
Professor Sinclair’s team now works with NASA to protect astronauts from DNA degradation caused by the powerful cosmic radiation in space. Especially in preparation for trips to Mars.
NAD+ will therefore help people who often fly, or undergo x-rays, but also sportsmen for whom it is a source of energy without equal!
People who undergo aggressive therapies against cancers, chemotherapy or radiation, will benefit enormously by taking good daily doses of NAD+ to protect their cells and repair the damage more quickly.
Biotrends offers the most cutting edge and efficient products, thanks to the work of its professionals, but also because Biotrends was created by enthusiasts who want to rejuvenate themselves!
Biotrends is born to offer the means to rejuvenate to the greatest number, not to make money, and that makes all the difference, and guarantees us of the seriousness and the quality of their products 🙂
See: magazine “Health Science and Conscience” n° 10 of June 2017. This issue also contains a big file on diet. Hurry up to find it again in the kiosks.
NAD+ is creating quite a buzz in scientific circles.
Nicotinamide Adenine Dinucleotide, or NAD+ for short, is used by every cell in the body. NAD+ is important because it is a big player in the energy production process within the mitochondria. Sirtuins, a class of enzymes well known for their role in regulating ageing, need NAD+ to do their job. And, research tells us that the tight integration between NAD+ availability and sirtuins activity is the major driver in controlling ageing factors and promoting longevity.
NAD+: A co-enzyme used by every living cell
NAD exists in two forms: NAD+ and NADH. NAD+ is the oxidized form of NAD. NAD+ levels decrease as we age, and scientists have established a solid inverse relationship between NAD+ levels and ageing.
How does NAD+ work?
NAD+ sits at the heart of the energy production process that occurs within the mitochondria – aptly called the ‘powerhouse of the cells’. How does it help in maintaining overall health and promoting longevity?
NAD+ improves mitochondrial functions
NAD+ activates Sirtuins, family of enzymes linked with regulating lifespan
Let’s explore the role of NAD+ in more detail.
NAD+ improves mitochondrial health
The cells in our body go through cycles of reproduction growth, repair and survival – and require tremendous energy to perform these myriad functions. Every cell in our body produces its own energy with all the action taking place in the mitochondria – tiny organelles within the cells. The energy is produced in a complex series of redox reactions, where NAD+ keeps shuttling between two forms; NAD+ and NADH.
NAD+ accepts electrons that are released during the burning or oxidation of organic fuels (fats, glucose), and in turn is reduced to NADH. NADH transfers the electrons in this ongoing chain of redox reactions – eventually resulting in ATP synthesis in a complicated yet highly organized process called oxidative phosphorylation. Clearly, NAD+ drives this process forward – that is, it facilitates the transfer of energy from the food to our cells – and thereby helps cells carry out their numerous functions that are so critical to our sustenance, physical and mental well-being, and survival.
What happens when NAD+ levels decline?
Reduced levels of NAD+ means the energy transfer takes a massive hit – resulting in impaired mitochondrial functions and increased oxidative stress, which in turn manifest as:
Reduced energy (ATP) production
Reduced heat production
Increased generation of damaging free radicals, causing damage to DNA, proteins and lipids
Reduced cellular ability to perform basic functions: healthy division, growth and repair damage triggered by oxidative stress
Mitochondrial dysfunction is believed to be one of the main reasons behind the symptoms of ageing, such as physical and cognitive decline, loss of energy and fatigue. Not surprisingly, with the mitochondria not working as smoothly and efficiently, cells become vulnerable to oxidative stress, hence trailed by premature ageing and age associated diseases such as heart failure, type 2 diabetes, insulin resistance, obesity, hearing loss, vision loss, Alzheimer’s disease and cancer.
NAD+ and Sirtuins: NAD+ activates Sirtuins
Internal structure of a cell.
Playing important roles in the process of ageing and mitochondrial fitness are sirtuins – SIR2 or silent information regulator 2 proteins. This family, so far as current research has identified, consists of seven enzymes (SIRT1–7). In mammals, Sirtuins control how the body responds to energy metabolism and stress – two factors at the core of the ageing process.
While sirtuins are found in different compartments of a cell, such as nucleus, cytoplasm and mitochondria, and may have unique functions, the predominant role of Sirtuins can still be summed up as:
To protect cells from stress and,
Enhance cellular capacity to develop resistance against stressors, survive and self-preserve, thus contributing to increasing life span.
And Sirtuins are dependent on NAD+ for their activity. In fact, Sirtuins also act as a substrate for other enzymes including bacterial DNA ligase, Poly-ADP-ribose Polymerases (PARPs) and CD38, with all these enzymes playing important role in cell survival. This competitive use of NAD+ among so many related ‘consumer’ enzymes is also one of the factors why NAD+ levels decline as we age.
Sirtuins: The magic behind the effects of calorie restriction (CR)
A low-calorie diet is one of most effective and proven strategies to keep ageing at bay. Even long before modern scientific studies, many traditional systems of medicine, such as Ayurveda, have long believed that calorie restriction (CR) is the road to achieve a long, healthy life. So, what is the mystery behind CR and anti-ageing benefits? How come depriving the body of calories can make you live longer?
It seems that Sirtuins hold the key to this puzzle. Of course, one of the theories backing the CR effect is that it reduces the formation of free radicals, invariably formed when our cells use nutrients and oxygen to create energy during the oxidative phosphorylation process. It is something like when a vehicle burns fuel and releases smoke as a by-product. With reduced generation of free radicals, cellular structures experience less oxidative damage, and function better.
However, more and more studies indicate there is something more interesting happening at the backend. It appears that CR drives some very targeted bio-chemical responses, which helps cells preserve themselves and survive under unfavorable conditions. And no points for guessing, sirtuins are believed to drive these biological responses.
CR achieves the anti-ageing effect by activating sirtuins. To be precise, CR increases the expression of SIRT1, SIRT3 and SIRT5, enzymes that are known to regulate the expressions of genes associated with ageing. So, increasing the bio-availability of cellular NAD+ and increasing Sirtuins activity to extend the lifespan (that mimics CR mechanism) makes complete sense as a strategy to combat ageing and diseases of ageing.
NAD+ and Sirtuins: The Complex Relationship
Sirtuin 6 protein. linked to longevity.
In the mitochondria, NAD+ levels mirror the energy status of the cell. And sirtuins function as sensors; detecting the variations in the NAD+ levels and processing this information to help cells adapt and survive fluctuating energy requirements. NAD+ availability decreases as we age, negatively impacting Sirtuin activity.
The complex relationship between NAD+ and Sirtuins helps in controlling metabolic and longevity pathways. Studies show that this tight integration between the availability of NAD+ and Sirtuins activity helps to:
Maintain the communication between the nucleus and mitochondria at a cellular level and;
Maintain the inter-tissue communication, more specifically between the hypothalamus and adipose tissue at a systemic level.
The integration of NAD+ and sirtuins orchestrates this important communication, both at cellular as well as systemic level. If this orchestration works smoothly, the result is melodious harmony that keeps cells healthy. However, with low NAD+ levels, this communication gets disrupted. Cells lose their ability to create sufficient energy and the process of ageing accelerates. Dr. David Sinclair, Harvard Medical School Professor of Genetics commented that “this communication network is like a married couple—when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down. And just as with a married couple, restoring communication solved the problem.”
Overall, NAD+ dependent Sirtuins protects against premature ageing and associated diseases through various mechanisms, such as:
Deacetylation of proteins like histones
Regulating metabolism and circadian rhythm
Boosting mitochondrial functions and response in the face of external or internal stress, for example fasting and oxidative damage
Reducing inflammation in the body
Boosts energy and fights premature ageing
Improves mitochondrial efficiency. Enhances energy metabolism. Reduces Oxidative stress.
Emerging research and scientific studies are all pointing to the role of NAD+ in improving human lifespan, quality of life and all-inclusive health. The evidence is promising and shows that boosting NAD+ levels can help us achieve a healthy and disease free life. Since oxidative stress and mitochondrial dysfunction are implicated in ageing and most heath conditions, NAD+ indeed is fast emerging as a real possibility to prevent and even reverse a wide range of chronic ailments, including:
Metabolic disorders, such as obesity, insulin resistance, type 2 diabetes
Neuro-degenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, dementia
Advances in anti-aging fight continue to be the focus of private conversations but also public ones.
It is only in recent years that we have seriously studied the possibilities of not growing old.
This dream that has existed since ancient times, is finally becoming reality.
Scientific and medical studies are in progress in thousands of laboratories all over the world.
Large tracks have already been released to approach the end of aging from various angles.
From the effects of nutrition to those of exercise, stress and environment on aging, all these parameters are studied closely for decades and yet people continue to die as before.
The conclusions are clear, unless we intervene at the cellular level to correct the damage caused by our cells themselves, by their inner operation, or more deeply yet by acting on our genes, there is no way to stop the degradation of our body.
I personally think that within 20 years we will have a good map of the importance of each of our genes, and we will have also discovered how to change our DNA to optimize and improve our organs and their functioning, our cells and our body in whole.
Many scientists predict a longer or even a doubling of our lifespan in 15 to 25 years from now.
Progress is rapid and accelerating exponentially, faster than we can predict or even imagine, because of the proliferation of advanced technologies and discoveries and investments in the area.
No worries then for those who love life, there is no more than 10 to 20 years to wait before it becomes super long!
It is on this waiting period that we must focus, to keep our body healthy and to keep it young as much as possible.
It is true that there are very few methods, not to say none, which allow today to reverse the course of time on our lives. As you know, I spend time almost every day to find the latest breakthroughs in rejuvenation, and I read hundreds of articles and many books on the subject. I also look at conferences and international scientific news on Youtube, and I even tried many products in the short, medium and long term.
In truth there is no large variety of really effective supplements!
Of course I take 2 grams of vitamin C every day for my cardiovascular system and my skin (it works because I have 0% arterial blockage) and eat as many ripe fruits and fresh vegetables as possible.
The only 2 supplements I take nowdays are the Nouvelle-Vie and NAD+ powder of BioTrends.
I make the financial choice to take 2 because they really make me great effect.
So which one to choose, Epitalon or NAD +, if you can not take both?
# Epitalon and Carnosine
Both are contained in N-V are known to lengthen telomeres, these little strands protect our DNA and allow proper duplication of our cells.
They thus make it possible to lengthen the life of each healthy cell, but also allows them to reproduce without DNA errors without degeneration. It is essential to staying young.
It acts not on DNA but on the mitochondria, the elements that produce ATP energy for the cells and the whole body.
NAD+ restores vitality to cells and thus the muscles and all organs, hence the sensation of full energy and athletic performance increase for those who take it.
But this cell revival and rejuvenation also allows them to rebuild and clean of wastes accumulated over the years, and therefore they can better function for their entire life.
Here you have it, these two supplements, which are virtually the only ones to really act, are in fact complementary, and the best is to take them both every day.
If you can not enjoy the two together, make a first test with the NAD+ for 1 month or two, I’m sure you will not want to stop … or try first Nouvelle-Vie and Epitalon if want just rejuvenate by lengthening your telomeres. Both products rejuvenate the cells and thus increase their longevity …
Anyway I urge you to take action today to take full advantage of this by extending your future!
Prof. Sinclair of the Medical School of Harvard University became famous last year thanks to his scientific study which has rejuvenated mice from 60 to 20 years.
But he and his Australian team had already discovered the anti-aging effects of resveratrol 10 years ago!
He is therefore not new in this field, and he has been looking for molecules against ageing for more than 20 years.
After resveratrol they decided to develop molecules even more powerful. The NAD+ had been discovered for several decades, but with his tests, Pr Sinclair showed the full potential of the NAD+ against aging!
It is therefore not the invention of a new molecule, but the discovery of the cellular mechanism that this coenzyme can repair, and thus prevent cell death and even make it possible to rejuvenate them.
Here is a small documentary published on Yahoo News, I transcribed it partially:
Prof. Sinclair has been studying aging for over 20 years. He participated in the discovery of resveratrol and its benefits. They discovered that by giving resveratrol to supercharged mice, they remained young and thin.
It is then that the frenzy for red wine and its resveratrol has started.
Prof Sinclair says they have made good progress since this discovery and are working on even more effective molecules.
Prof Sinclair: NAD is our latest discovery. For example you can lengthen the life of a mouse that has liver cancer. We hope that this molecule will help humans with cancers.03mn00: Pr Sinclair: Our human cells contain mitochondria, and this is very important against aging because without them the cells die within seconds. So it’s vital, energy is produced.
And when we age, these small batteries nece ssary to produce energy diminish much, they disappear.
And this molecule that we discovered makes it possible to reverse very quickly the aging of these mitochondria, in such a way that they become young again.
03mn30: Pr Sinclair: One of the most important points we have studied is the possibility of protecting the brain because it is useless to keep the body young if the brain does not work properly.
So we looked at whether these protective effects spread to the brain, and the answer is yes!
Mice are thus protected against Alzheimer, Parkinson and others, and they become even more intelligent.
Despite numerous attacks on their work, Professor Sinclair’s team continues to publish his findings, and no one has ever provided any evidence against the validity of their results.
We check our studies, we reproduce them several times, and the results are always there.04mn20: Journalist: Prof Sinclair is so sure of his results that he himself tries the molecules they have discovered.
04mn25: Pr Sinclair: It is common knowledge that I have been taking resveratrol for 10 years already, and I feel good. My parents have been taking it for 10 years too, and they are still in good shape at over 70 years old.
My father is 75 years old and is in better shape than I am!
05mn25: Pr SInclair: I do not see any limit to the human lifetime. Let us live up to 100 years, I have no doubt. I do not doubt that one day we will live until 150 years, on the other hand I do not know when it will happen.
Here Prof Sinclair explains his career and his discoveries, including resveratrol, on TED in 2013:
I hope to have time to translate other documents on the NAD+ because I have found many others, but do not wait any longer to try it.We are really in an incredible time, where scientists have the means to study closely the functioning of our bodies and find ways to repair it and prevent it from degrading.